Evolution and spread of antibiotic resistance
نویسندگان
چکیده
منابع مشابه
Antibiotic Resistance: Origins, Evolution, Selection and Spread
Antibiotic resistance thwarts the treatment of infectious diseases worldwide. Although a number of factors can be identified which contribute to the problem, clearly the antibiotic as a selective agent and the resistance gene as the vehicle of resistance are the two most important, making up a 'drug resistance equation'. Both are needed in order for a clinical problem to arise. Given sufficient...
متن کاملEvolution of Antibiotic Resistance
Pietsch, F. 2015. Evolution of Antibiotic Resistance. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1150. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9380-6. The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many i...
متن کاملModeling the Spread of Antibiotic Resistance
This paper describes a stochastic implementation of Austin et al.’s (1999) model of the spread of antibiotic resistance in a population of fixed size under varying conditions of antibiotic use. The population is divided into sub-groups: individuals colonized by commensal bacteria and an uncolonized group. The colonized group is further divided according to whether the commensal bacteria are sen...
متن کاملOrigin and Evolution of Antibiotic Resistance: The Common Mechanisms of Emergence and Spread in Water Bodies
The environment, and especially freshwater, constitutes a reactor where the evolution and the rise of new resistances occur. In water bodies such as waste water effluents, lakes, and rivers or streams, bacteria from different sources, e.g., urban, industrial, and agricultural waste, probably selected by intensive antibiotic usage, are collected and mixed with environmental species. This may cau...
متن کاملEvolution of Antibiotic Resistance without Antibiotic Exposure
Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evol...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2002
ISSN: 0954-6820,1365-2796
DOI: 10.1046/j.1365-2796.2002.01026.x